An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS.
Genetic mutations of FUS have been linked to many diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration.A primate specific and polymorphic retrotransposon of the SINE-VNTR-Alu (SVA) family is present upstream of the FUS gene.Here we have demonstrated that this retrotransposon frog castanet can act as a classic